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Article

Mesangial Cell-Specific Antibodies Are Central to the Pathogenesis of Lupus Nephritis

28 Nov 2011

Abstract excerpt

Not only is nephritis a common complaint in systemic lupus erythematosus, but it is also the most life-threatening complication of the disease. Anti-double-stranded DNA antibodies (Abs), which are found in up to 80% of these patients, might be nephritogenic per se. That is, they may cross-react with mesangial cell (MC) surface proteins, such as alpha-actinin and annexin A2, they may cross-react with mesangial...

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PMID: 22162716
DOI: 10.1155/2012/579670

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