Article
Identification of two distinct elements mediating activation of telomerase (hTERT) gene expression in association with cell growth in human T cells.
International immunology - 1 Feb 2005
Matsumura-Arioka Yuuki, Ohtani Kiyoshi, Hara Toshifumi, Iwanaga Ritsuko, Nakamura Masataka
Abstract excerpt
Lymphocytes are exceptional among normal somatic cells in that they express high telomerase activity like germline and malignant cells. We investigated the induction of telomerase in human T cells in association with cell growth. IL-2 significantly augmented the expression of mRNA for human telomerase reverse transcriptase (hTERT), a rate-limiting component of telomerase, in PHA-activated human peripheral blood...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
