Article
CD8-positive adult T-cell leukemia cells with an integrated defective HTLV-I genome show a paracrine growth to IL-2.
American journal of hematology - 1 Oct 1994
Matsushita K, Arima N, Hidaka S, Ohtsubo H, Fujiwara H, Fukumori J, Tanaka H
Abstract excerpt
We describe a 50-year-old man with adult T-cell leukemia complicated by laryngeal tuberculosis whose tumor cells proliferate in response to IL-2 in a paracrine manner. On admission, the patient's white blood cell count was 17,900/mm3; 73% were abnormal lymphocytes with convoluted nuclei. FACS ana...
Topics
- Blotting, Northern
- Blotting, Southern
- CD8 Antigens
- Cell Division
- Cell Nucleus
- Genome, Viral
- Human T-lymphotropic virus 1
- Humans
- Interleukin-2
- Leukemia, T-Cell
- Male
- Middle Aged
- Phenotype
- RNA, Messenger
- T-Lymphocytes
- Tumor Cells, Cultured