Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

IL-2- and STAT5-regulated cytokine gene expression in cells expressing the Tax protein of HTLV-1.

Oncogene - 7 Jul 2005

Fung Michelle M, Chu Yen-Lin, Fink J Lynn, Wallace Anne, McGuire Kathleen L

Abstract excerpt

Interleukin-2 (IL-2) mediates cell cycle progression and antiapoptosis in human T cells via several signal transduction pathways. The Tax protein of the human T-cell leukemia virus type I (HTLV-1) deregulates cell growth and alters the role of IL-2 in infected cells. However, Tax-immortalized cel...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Culture Techniques
Share to Gene Products, tax
Share to Human T-lymphotropic virus 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Interleukin-2

Share to Milk Proteins

Share to STAT5 Transcription Factor

Share to Thymus Gland

Share to Trans-Activators

Source

Identifiers

PMID: 15735688
DOI: 10.1038/sj.onc.1208507

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-15735688-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

IL-2- and STAT5-regulated cytokine gene expression in cells expressing the Tax protein of HTLV-1.PMID 15735688Read ↗

Molecular mechanisms of cellular transformation by HTLV-1 Tax.Semantic proximity Read ↗

Intracellular Localization and Cellular Factors Interaction of HTLV-1 and HTLV-2 Tax Proteins: Similarities and Functional DifferencesSemantic proximity Read ↗

JAK–STAT and JAK–PI3K–mTORC1 Pathways Regulate Telomerase Transcriptionally and Posttranslationally in ATL CellsSemantic proximity Read ↗

Central role of PI3K in transcriptional activation of hTERT in HTLV-I–infected cellsSemantic proximity Read ↗

DIFFERENTIAL REGULATION OF HUMAN T LYMPHOBLAST FUNCTIONS BY IL-2 AND IL-15Semantic proximity Read ↗

Triple synergism of human T-lymphotropic virus type 1-encoded tax, GATA-binding protein, and AP-1 is required for constitutive expression of the interleukin-5 gene in adult T-cell leukemia cells.Semantic proximity Read ↗

Activation of interleukin-13 expression in T cells from HTLV-1-infected individuals and in chronically infected cell linesSemantic proximity Read ↗

HIV-1 transactivator protein induction of suppressor of cytokine signaling-2 contributes to dysregulation of IFNγ signalingSemantic proximity Read ↗

Human T-cell leukemia virus type 2 tax mutants that selectively abrogate NFkappaB or CREB/ATF activation fail to transform primary human T cells.Semantic proximity Read ↗

STAT2 Is a Pervasive Cytokine Regulator due to Its Inhibition of STAT1 in Multiple Signaling PathwaysSemantic proximity Read ↗

An activating mutation of interferon regulatory factor 4 (IRF4) in adult T-cell leukemia.Semantic proximity Read ↗

A novel positive feedback-loop between the HTLV-1 oncoprotein Tax and NF-κB activity in T-cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.