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Article

Acetylcholinesterase/paraoxonase interactions increase the risk of insecticide-induced Parkinson's disease.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Mar 2005

Benmoyal-Segal Liat, Vander Tatiana, Shifman Sagiv, Bryk Boris, Ebstein Richard P, Marcus Esther-Lee, Stessman Jochanan, Darvasi Ariel, Herishanu Yuval, Friedman Alon, Soreq Hermona

Abstract excerpt

Exposure to agricultural insecticides, together with yet incompletely understood predisposing genotype/phenotype elements, notably increase the risk of Parkinson's disease. Here, we report findings attributing the increased risk in an insecticide-exposed rural area in Israel to interacting debilitating polymorphisms in the ACHE/PON1 locus and corresponding expression variations. Polymorphisms that debilitate PON1...

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Source

Identifiers

PMID: 15629887
DOI: 10.1096/fj.04-2106fje

Genes

PON1
ACHE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Acetylcholinesterase/paraoxonase interactions increase the risk of insecticide-induced Parkinson's disease.PMID 15629887Read ↗

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