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Article

Biophysical characterization of an ensemble of intramolecular i-motifs formed by the human c-MYC NHE III1 P1 promoter mutant sequence.

Biophysical journal - 21 Jul 2010

Dettler Jamie M, Buscaglia Robert, Cui Jingjing, Cashman Derek, Blynn Meredith, Lewis Edwin A

Abstract excerpt

i-Motif-forming sequences are present in or near the regulatory regions of >40% of all genes, including known oncogenes. We report here the results of a biophysical characterization and computational study of an ensemble of intramolecular i-motifs that model the polypyrimidine sequence in the human c-MYC P1 promoter. Circular dichroism results demonstrate that the mutant sequence (5'-CTT TCC TAC CCTCCC TAC CCT...

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Identifiers

PMID: 20643075
DOI: 10.1016/j.bpj.2010.04.042
PMCID: PMC2905117

Genes

MYC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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