Article
Functional analysis of the p53 pathway in neuroblastoma cells using the small-molecule MDM2 antagonist nutlin-3.
Molecular cancer therapeutics - 1 Jun 2011
Van Maerken Tom, Rihani Ali, Dreidax Daniel, De Clercq Sarah, Yigit Nurten, Marine Jean-Christophe, Westermann Frank, De Paepe Anne, Vandesompele Jo, Speleman Frank
Abstract excerpt
Suppression of p53 activity is essential for proliferation and survival of tumor cells. A direct p53-activating compound, nutlin-3, was used in this study, together with p53 mutation analysis, to characterize p53 pathway defects in a set of 34 human neuroblastoma cell lines. We identified 9 cell lines (26%) with a p53 loss-of-function mutation, including 6 missense mutations, 1 nonsense mutation, 1 in-frame...
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