Article
mdm2 gene amplification and overexpression in non-small cell lung carcinomas with accumulation of the p53 protein in the absence of p53 gene mutations.
Diagnostic molecular pathology : the American journal of surgical pathology, part B - 1 Jun 1995
Marchetti A, Buttitta F, Pellegrini S, Merlo G, Chella A, Angeletti C A, Bevilacqua G
Abstract excerpt
Fifty-three non-small cell lung carcinomas (NSCLC), previously investigated for p53 abnormalities, were studied to evaluate the status of the mdm2 gene by Southern and Northern blot analysis and expression of the mdm2 protein by immunohistochemistry with specific monoclonal antibodies. Amplificat...
Topics
- Base Sequence
- Carcinoma, Non-Small-Cell Lung
- Gene Amplification
- Humans
- Lung Neoplasms
- Molecular Sequence Data
- Mutation
- Proto-Oncogenes
- Tumor Suppressor Protein p53