Article
Isolation and characterization of cDNAs encoding PDE5A, a human cGMP-binding, cGMP-specific 3',5'-cyclic nucleotide phosphodiesterase.
Gene - 17 Aug 1998
Loughney K, Hill T R, Florio V A, Uher L, Rosman G J, Wolda S L, Jones B A, Howard M L, McAllister-Lucas L M, Sonnenburg W K, Francis S H, Corbin J D, Beavo J A, Ferguson K
Abstract excerpt
Human cGMP-binding, cGMP-specific 3',5'-cyclic nucleotide phosphodiesterase (PDE5A) cDNAs were isolated. A 3.1-kb composite DNA sequence assembled from overlapping cDNAs encodes an 875-amino-acid protein with a predicted molecular mass of 100012 Da (PDE5A1). Extracts prepared from yeast expressin...
Topics
- 3',5'-Cyclic-GMP Phosphodiesterases
- Alternative Splicing
- Amino Acid Sequence
- Animals
- Aorta
- Base Sequence
- Blotting, Northern
- Cattle
- Chromosome Mapping
- Chromosomes, Human, Pair 4
- Cyclic Nucleotide Phosphodiesterases, Type 5
- DNA, Complementary
- Gene Expression