Bioluminescence temporal signatures of monocyte differentiation reveals changes in phenotype due to GM-CSF, M-CSF, and PMA induction.

doi:10.1016/j.diff.2026.100977

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Article

Bioluminescence temporal signatures of monocyte differentiation reveals changes in phenotype due to GM-CSF, M-CSF, and PMA induction.

Differentiation; research in biological diversity - 1 Jan 2026

James Zachary, Li Colette, Spassennikova Anna, Zheng Shiyuan, Brown Chloe, Anand Megha, Chiang Yi-Hsuan, Wayne Elizabeth

Abstract excerpt

Human THP-1 monocyte-like cells are a commonly used model for monocyte-derived macrophages (MoDM) in vitro, and significant literature has demonstrated how MoDM phenotype depends on the type, concentration, and duration of differentiation stimuli. However, far less attention has been given to how the choice of differentiation protocols actively reprograms transcriptional signaling networks during the...

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Topics

Humans
Granulocyte-Macrophage Colony-Stimulating Factor
Cell Differentiation
Monocytes
Tetradecanoylphorbol Acetate

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Macrophage Colony-Stimulating Factor

Macrophages

THP-1 Cells

Phenotype

NF-kappa B

Signal Transduction

STAT6 Transcription Factor

Luminescent Measurements

Gene Expression Regulation

Source

Open in PubMed

Identifiers

PMID: 42462340
DOI: 10.1016/j.diff.2026.100977

Genes

STAT6

Provenance

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