Article
Different role of functional domains of hTR in DNA binding to telomere and telomerase reconstruction.
FEBS letters - 3 Jan 2005
Yeo M, Rha S Y, Jeung H C, Shen X H, Yang S H, An S W, Roh J K, Chung H C
Abstract excerpt
Even if template sequence of hTR played an essential role in telomere binding, a 326 nucleotide fragment of hTR containing template, pseudoknot, and CR4-5 domains is critical for both binding with telomeric DNA and reconstitution of telomerase activity. A functional study with antisense oligonucleotides suggested that targeted disruption of the template region efficiently abrogated both telomeric DNA binding and...
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