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Article

Analysis of the structure of human telomerase RNA in vivo

15 Feb 2002

Abstract excerpt

Telomerase is a ribonucleoprotein reverse transcriptase that synthesises telomeric DNA. The RNA component of telomerase acts as a template for telomere synthesis and binds the reverse transcriptase. In this study, we have performed in vivo and in vitro structural analyses of human telomerase RNA (hTR). In vivo mapping experiments showed that the 5'-terminal template domain of hTR folds into a long hairpin...

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Share to RNA and protein synthesis mechanisms
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Share to Telomeres, Telomerase, and Senescence

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PMID: 11842102
DOI: 10.1093/nar/30.4.912

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