Article
Pheromone-induced polarization is dependent on the Fus3p MAPK acting through the formin Bni1p.
The Journal of cell biology - 1 Apr 2004
Matheos Dina, Metodiev Metodi, Muller Eric, Stone David, Rose Mark D
Abstract excerpt
During mating, budding yeast cells reorient growth toward the highest concentration of pheromone. Bni1p, a formin homologue, is required for this polarized growth by facilitating cortical actin cable assembly. Fus3p, a pheromone-activated MAP kinase, is required for pheromone signaling and cell fusion. We show that Fus3p phosphorylates Bni1p in vitro, and phosphorylation of Bni1p in vivo during the pheromone...
Topics
- Actin Cytoskeleton
- Cell Movement
- Cell Polarity
- Cell Size
- Cytoskeletal Proteins
- GTP-Binding Proteins
- Gene Expression Regulation, Fungal
- Microfilament Proteins
- Microtubules
- Mitogen-Activated Protein Kinases
- Mutation
- Nuclear Proteins
- Pheromones