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Article

Control of MAPK signaling specificity by a conserved residue in the MEK-binding domain of the yeast scaffold protein Ste5.

Current genetics - 1 Jun 2006

Schwartz Monica A, Madhani Hiten D

Abstract excerpt

The yeast kinase scaffold Ste5 has been proposed to prevent unwanted cross-talk between the pheromone response pathway and other MAPK cascades. Protein fusion experiments have demonstrated that covalently tethering signaling components to each other or to Ste5 can determine the outcome of signaling. However, these do not fully test the role of scaffolds in signaling specificity, since fusing components precludes...

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Share to Conserved Sequence
Share to Genes, Mating Type, Fungal
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16463042
DOI: 10.1007/s00294-006-0061-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Control of MAPK signaling specificity by a conserved residue in the MEK-binding domain of the yeast scaffold protein Ste5.PMID 16463042Read ↗

Signaling in the yeast pheromone response pathway: specific and high-affinity interaction of the mitogen-activated protein (MAP) kinases Kss1 and Fus3 with the upstream MAP kinase kinase Ste7.Semantic proximity Read ↗

Persistent activation by constitutive Ste7 promotes Kss1-mediated invasive growth but fails to support Fus3-dependent mating in yeast.Semantic proximity Read ↗

A conserved docking site in MEKs mediates high-affinity binding to MAP kinases and cooperates with a scaffold protein to enhance signal transmission.Semantic proximity Read ↗

The scaffold protein Ste5 directly controls a switch-like mating decision in yeast.Semantic proximity Read ↗

Dual role for membrane localization in yeast MAP kinase cascade activation and its contribution to signaling fidelity.Semantic proximity Read ↗

Dimerization of Ste5, a mitogen-activated protein kinase cascade scaffold protein, is required for signal transduction.Semantic proximity Read ↗

Localized feedback phosphorylation of Ste5p scaffold by associated MAPK cascade.Semantic proximity Read ↗

Functional binding between Gbeta and the LIM domain of Ste5 is required to activate the MEKK Ste11.Semantic proximity Read ↗

Association of the yeast pheromone response G protein beta gamma subunits with the MAP kinase scaffold Ste5p.Semantic proximity Read ↗

Function of the MAPK scaffold protein, Ste5, requires a cryptic PH domain.Semantic proximity Read ↗

The MAP kinase Fus3 associates with and phosphorylates the upstream signaling component Ste5.Semantic proximity Read ↗

Fus3-regulated Tec1 degradation through SCFCdc4 determines MAPK signaling specificity during mating in yeast.Semantic proximity Read ↗

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