Article
Heterozygosity in CTLA-4 gene and severe preeclampsia.
International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics - 1 Jan 2005
Samsami Dehaghani A, Doroudchi M, Kalantari T, Pezeshki A M, Ghaderi A
Abstract excerpt
OBJECTIVE: One of the major complications of pregnancy, preeclampsia makes pregnancy termination inevitable in most cases. Similarities exist between the mechanisms that maintain normal pregnancy, allograft transplants, and, it is postulated, peripheral self-tolerance. In addition, the critical role of the cytotoxic T-lymphocyte antigen-4 (CTLA-4) molecule in maintaining self-tolerance has been established....
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