Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Maternal and Fetal HLA Heterozygosity in Preeclampsia: Insights From a Large Multi-Ancestry Pregnancy Cohort.

HLA - 1 Sept 2026

Cao Chang, Maher Matthew, Hu Jie, Keating Brendan J, Burwick Richard M, Karumanchi S Ananth, Maxwell G Larry, Powe Camille E, McElrath Thomas F, Cantonwine David E, Serrano Norma, Colmenares Claudia, Casas Juan P, Saxena Richa, Gray Kathryn J

Abstract excerpt

Preeclampsia (PE) is a leading cause of maternal and neonatal morbidity, with immune dysregulation at the maternal-fetal interface central to its pathogenesis. The highly polymorphic HLA region mediates maternal immune tolerance of the semi-allogeneic fetus, yet the contribution of HLA diversity to PE risk remains poorly defined. Whether the HLA heterozygote advantage observed in other immune disorders is...

Read the complete abstract on PubMed

Topics

Humans
Female
Pregnancy
Pre-Eclampsia
Heterozygote
Adult

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

HLA Antigens

Genetic Predisposition to Disease

Alleles

Fetus

Source

Open in PubMed Open full text

Identifiers

PMID: 42728216
DOI: 10.1111/tan.70970
PMCID: PMC13569466

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Maternal and Fetal HLA Heterozygosity in Preeclampsia: Insights From a Large Multi-Ancestry Pregnancy Cohort.PMID 42728216Read ↗

Maternal and fetal HLA heterozygosity in preeclampsia: Insights from a large multi-ancestry pregnancy cohortSemantic proximity Read ↗

High maternal-fetal HLA eplet compatibility is associated with severe manifestation of preeclampsiaSemantic proximity Read ↗

Distribution of HLA-G extended haplotypes and one HLA-E polymorphism in a large-scale study of mother-child dyads with and without severe preeclampsia and eclampsia.Semantic proximity Read ↗

Meta-analysis of the human leukocyte antigen-G (HLA-G) 14 bp insertion/deletion polymorphism as a risk factor for preeclampsia.Semantic proximity Read ↗

Analysis of HLA-G long-read genomic sequences in mother-offspring pairs with preeclampsia.Semantic proximity Read ↗

Balancing Selection at <i>HLA-G</i> Modulates Fetal Survival, Preeclampsia and Human Birth Sex RatioSemantic proximity Read ↗

Maternal-Fetal HLA Compatibility in Uncomplicated and Preeclamptic Naturally Conceived PregnanciesSemantic proximity Read ↗

The role of genetics in maternal susceptibility to preeclampsia in women of African ancestry.Semantic proximity Read ↗

Human Leukocyte Antigens in Pregnancy and PreeclampsiaSemantic proximity Read ↗

Maternal-Foetal HLA-DQB1 Incompatibility Is Associated With Pregnancy-Induced Hypertensive Disorders in a Genetically Isolated Population.Semantic proximity Read ↗

Association between HLA-A gene polymorphism and early-onset preeclampsia in Chinese pregnant women early-onset.Semantic proximity Read ↗

Fetal HLA-G mediated immune tolerance and interferon response in preeclampsia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.