CTLA-4 polymorphism 49A-G is associated with placental abruption and preeclampsia in Finnish women.

doi:10.1515/CCLM.2008.034

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Article

CTLA-4 polymorphism 49A-G is associated with placental abruption and preeclampsia in Finnish women.

Clinical chemistry and laboratory medicine - 1 Jan 2008

Jääskeläinen Ester, Toivonen Sari, Keski-Nisula Leea, Paattiniemi Eeva-Liisa, Helisalmi Seppo, Punnonen Kari, Heinonen Seppo

Abstract excerpt

BACKGROUND: Our aim was to study genetic variability in the gene encoding cytotoxic T-lymphocyte antigen (CTLA-4) and individual susceptibility to the development of preeclampsia or placental abruption. METHODS: A total of 361 women (132 with preeclampsia, 117 with placental abruption and 112 healthy controls) were genotyped for 49A-G polymorphism (dbSNP: rs231775) in the CTLA-4 gene. RESULTS: The frequency of...

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PMID: 18076363
DOI: 10.1515/CCLM.2008.034

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