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Association between HLA-G 14bp Gene Polymorphism and Serum sHLA-G Protein Concentrations in Preeclamptic Patients and Normal Pregnant Women.

Immunological investigations - 1 Aug 2018

Rokhafrooz Saber, Ghadiri Ata, Ghandil Pegah, Ghafourian Mehri, Hossaini Seyed Hojjat, Daraei Nahid, Najafian Mahin, Rouhizadeh Ahmad

Abstract excerpt

BACKGROUND: Preeclampsia (PE) is a multisystem syndrome that is a primary source of fetal-maternal morbidity and mortality. Human leukocyte antigen-G (HLA-G) is a nonclassical Major histocompatibility complex (MHC) class-Ib molecule expressed on the extravillous trophoblast and seems to have immunomodulatory functions during pregnancy. The purpose of our study was to investigate whether HLA-G may be a vital...

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Identifiers

PMID: 29952661
DOI: 10.1080/08820139.2018.1467925

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