Variation in the urokinase-plasminogen activator gene does not explain the chromosome 10 linkage signal for late onset AD.

doi:10.1002/ajmg.b.20036

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Article

Variation in the urokinase-plasminogen activator gene does not explain the chromosome 10 linkage signal for late onset AD.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Jan 2004

Myers Amanda J, Marshall Helen, Holmans Peter, Compton Danielle, Crook Richard J P, Mander Adrian P, Nowotny Petra, Smemo Scott, Dunstan Melanie, Jehu Luke, Wang Jen C, Hamshere Marian, Morris John C, Norton Joanne, Chakraventy Sumi, Tunstall Nigel, Lovestone Simon, Petersen Ronald, O'Donovan Michael, Jones Lesley, Williams Julie, Owen Michael J, Hardy John, Goate Alison

Abstract excerpt

Linkage studies indicate that the same region of chromosome 10 contains a risk locus for late onset Alzheimer disease (LOAD) and a QTL for plasma Abeta42 levels suggesting that a single locus may influence risk for AD by elevating plasma Abeta42 [Ertekin-Taner et al., 2000; Myers et al., 2000]. A strong positional and biological candidate is the urokinase-plasminogen activator (PLAU) gene. Eight polymorphisms...

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PMID: 14681909
DOI: 10.1002/ajmg.b.20036

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PLAU

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Variation in the urokinase-plasminogen activator gene does not explain the chromosome 10 linkage signal for late onset AD.PMID 14681909Read ↗

No association of a non-synonymous PLAU polymorphism with Alzheimer's disease and disease-related traits.Semantic proximity Read ↗

Elevated amyloid beta protein (Abeta42) and late onset Alzheimer's disease are associated with single nucleotide polymorphisms in the urokinase-type plasminogen activator gene.Semantic proximity Read ↗

Association of late-onset Alzheimer disease with a genotype of PLAU, the gene encoding urokinase-type plasminogen activator on chromosome 10q22.2.Semantic proximity Read ↗

A functional polymorphism within plasminogen activator urokinase (PLAU) is associated with Alzheimer's disease.Semantic proximity Read ↗

Gene Association Study of the Urokinase Plasminogen Activator and Its Receptor Gene in Alzheimer's Disease.Semantic proximity Read ↗

The urokinase-type plasminogen activator polymorphism PLAU_1 is a risk factor for APOE-epsilon4 non-carriers in the Italian Alzheimer's disease population and does not affect the plasma Abeta(1-42) level.Semantic proximity Read ↗

No association between SNP rs498055 on chromosome 10 and late-onset Alzheimer disease in multiple datasets.Semantic proximity Read ↗

Association of tagSNPs in the urokinase-plasminogen activator (PLAU) gene with Alzheimer's disease and associated quantitative traits.Semantic proximity Read ↗

Lack of association of two chromosome 10q24 SNPs with Alzheimer's disease.Semantic proximity Read ↗

Linkage of plasma Abeta42 to a quantitative locus on chromosome 10 in late-onset Alzheimer's disease pedigrees.Semantic proximity Read ↗

Substantial linkage disequilibrium across the insulin-degrading enzyme locus but no association with late-onset Alzheimer's disease.Semantic proximity Read ↗

Association analysis of genes involved in cholesterol metabolism located within the linkage region on chromosome 10 and Alzheimer's disease.Semantic proximity Read ↗

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