Article
No association of a non-synonymous PLAU polymorphism with Alzheimer's disease and disease-related traits.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Jan 2005
Papassotiropoulos Andreas, Tsolaki Magdalini, Wollmer M Axel, Molyva Dimitra, Thal Dietmar R, Huynh Kim-Dung, Tracy Jay, Staehelin Hannes B, Monsch Andreas U, Nitsch Roger M, Hock Christoph
Abstract excerpt
A 30 cM broad genomic region on the long arm of chromosome 10 at 80 cM shows significant and consistent linkage with AD and with plasma concentration of the beta-amyloid peptide 1-42 (Abeta42). The PLAU gene, which is involved in the production and degradation of Abeta42, maps to that region and is therefore a strong positional candidate for association with sporadic AD. We analyzed the non-synonymous single...
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