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The Human Papillomavirus Type 18 E2 Protein Is a Cell Cycle-Dependent Target of the SCF Skp2 Ubiquitin Ligase

15 Oct 2009

Abstract excerpt

The human papillomavirus type 18 (HPV-18) E2 gene is inactivated in cervical carcinoma after integration of the viral DNA into the host cellular genome. Since E2 represses the transcription of the two viral oncogenes E6 and E7, integration which allows their strong expression is considered a major step in transformation by HPV. We show here that E2 is specifically degraded at the end of the G(1) phase in a...

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PMID: 19828607
DOI: 10.1128/jvi.01162-09

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