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Article

Regulated stability of eukaryotic elongation factor 2 kinase requires intrinsic but not ongoing activity.

The Biochemical journal - 15 Apr 2015

Wang Xuemin, Xie Jianling, da Mota Sergio Regufe, Moore Claire E, Proud Christopher G

Abstract excerpt

Eukaryotic elongation factor 2 kinase (eEF2K) is an atypical protein kinase which negatively regulates protein synthesis, is activated under stress conditions and plays a role in cytoprotection, e.g. in cancer cells. It is regarded as a possible target for therapeutic intervention in solid tumours. Earlier studies showed that eEF2K is degraded by a proteasome-dependent pathway in response to genotoxic stress and...

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Identifiers

PMID: 25670349
DOI: 10.1042/BJ20150089

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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