Article
Elevated beta1,4-galactosyltransferase I in highly metastatic human lung cancer cells. Identification of E1AF as important transcription activator.
The Journal of biological chemistry - 1 Apr 2005
Zhu Xiaoyu, Jiang Jianhai, Shen Hailian, Wang Hanzhou, Zong Hongliang, Li Zejuan, Yang Yanzhong, Niu Ziyue, Liu Weicheng, Chen Xiaoning, Hu Yun, Gu Jianxin
Abstract excerpt
The elevated levels of beta1,4-galactosyltransferase I (GalT I; EC 2.4.1.38) are detected in highly metastatic lung cancer PGBE1 cells compared with its less metastatic partner PGLH7 cells. Decreasing the GalT I surface expression by small interfering RNA or interfering with the surface of GalT I function by mutation inhibited cell adhesion on laminin, the invasive potential in vitro, and tyrosine phosphorylation...
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