Article
Dominant negative mutation in cell surface beta 1,4-galactosyltransferase inhibits cell-cell and cell-matrix interactions.
The Journal of cell biology - 1 Feb 1993
Evans S C, Lopez L C, Shur B D
Abstract excerpt
In addition to its traditional location within the Golgi complex, beta 1,4-galactosyltransferase (GalTase) is also present on the cell surface, where it is thought to function as a cell adhesion molecule by binding to extracellular oligosaccharide ligands. Recent studies suggest that cells contai...
Topics
- 3T3 Cells
- Animals
- Cell Adhesion
- Cell Compartmentation
- Cell Membrane
- Cells, Cultured
- Cloning, Molecular
- Cytoskeleton
- DNA
- Extracellular Matrix
- Galactosyltransferases
- Genes, Dominant
- Glycoproteins
- In Vitro Techniques
- Mice
- Mutation
- Protein Processing, Post-Translational
- Structure-Activity Relationship