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Regulation of the GnT-V Promoter by Transcription Factor Ets-1 in Various Cancer Cell Lines

1 Aug 1999

Abstract excerpt

Although the precise role of oligosaccharides in metastasis is presently unknown, numerous studies suggest that the beta1-6 branching structure of N-linked oligosaccharides plays a role in tumor metastasis. N-Acetylglucosaminyltransferase V (GnT-V), which catalyzes the formation of the beta1-6 branch, therefore appears to play a crucial role in tumor metastasis. Recently, we demonstrated that the expression of...

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PMID: 10438459
DOI: 10.1074/jbc.274.33.22941

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