Article
Novel alleles of Plasmodium falciparum dhfr that confer resistance to chlorcycloguanil.
Molecular and biochemical parasitology - 1 Jan 2005
Hunt Sonia Y, Rezvani Brian B, Sibley Carol Hopkins
Abstract excerpt
In Plasmodium falciparum, resistance to folate inhibitors like pyrimethamine is mediated by point mutations in the target gene dihydrofolate reductase (dhfr). The resistance to pyrimethamine increases with the accumulation of particular point mutations. These mutations also confer increased resistance to chlorcycloguanil, the active metabolite of chlorproguanil and one component of a newly introduced DHFR...
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