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Article

Malaria antifolate resistance with contrasting Plasmodium falciparum dihydrofolate reductase (DHFR) polymorphisms in humans and Anopheles mosquitoes.

Proceedings of the National Academy of Sciences of the United States of America - 15 Nov 2011

Mharakurwa Sungano, Kumwenda Taida, Mkulama Mtawa A P, Musapa Mulenga, Chishimba Sandra, Shiff Clive J, Sullivan David J, Thuma Philip E, Liu Kun, Agre Peter

Abstract excerpt

Surveillance for drug-resistant parasites in human blood is a major effort in malaria control. Here we report contrasting antifolate resistance polymorphisms in Plasmodium falciparum when parasites in human blood were compared with parasites in Anopheles vector mosquitoes from sleeping huts in rural Zambia. DNA encoding P. falciparum dihydrofolate reductase (EC 1.5.1.3) was amplified by PCR with allele-specific...

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Identifiers

PMID: 22065788
DOI: 10.1073/pnas.1116162108
PMCID: PMC3219121

Genes

DHFR

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Source receipt: pubmed, retrieved 7 Sept 2026.

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