Article
Antifolate resistance due to new and known Plasmodium falciparum dihydrofolate reductase mutations expressed in yeast.
Molecular and biochemical parasitology - 1 Aug 1998
Cortese J F, Plowe C V
Abstract excerpt
Two new dihydrofolate reductase (DHFR) mutations were recently discovered in Plasmodium falciparum samples from an area of Bolivia with high rates of in vivo resistance to pyrimethamine-sulfadoxine: a Cys-->Arg point mutation in codon 50 and a five amino acid insertion after codon 30, termed the...
Topics
- Animals
- Antimalarials
- Bolivia
- DNA, Protozoan
- Drug Resistance
- Folic Acid Antagonists
- Malaria, Falciparum
- Mutation
- Plasmodium falciparum
- Proguanil
- Recombinant Proteins
- Saccharomyces cerevisiae
- Tetrahydrofolate Dehydrogenase
- Transformation, Genetic