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Article

Molecular basis of differential resistance to cycloguanil and pyrimethamine in Plasmodium falciparum malaria.

Proceedings of the National Academy of Sciences of the United States of America - 1 Apr 1990

Peterson D S, Milhous W K, Wellems T E

Abstract excerpt

Proguanil and pyrimethamine are antifolate drugs with distinct chemical structures that are used commonly in the prophylaxis and treatment of Plasmodium falciparum malaria. Clinical reports and field studies have suggested that some parasites refractory to proguanil can be treated with pyrimethamine, and vice versa. Analysis of the P. falciparum dihydrofolate reductase (DHFR) from different parasites reveals the...

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Identifiers

PMID: 2183222
DOI: 10.1073/pnas.87.8.3018
PMCID: PMC53825

Genes

DHFR

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Molecular basis of differential resistance to cycloguanil and pyrimethamine in Plasmodium falciparum malaria.PMID 2183222Read ↗

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