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Article

5‐Aza‐2′‐deoxycytidine induces p21<sup>WAF</sup> expression by demethylation of p73 leading to p53‐independent apoptosis in myeloid leukemia

17 Dec 2004

Abstract excerpt

The DNA methylation inhibitor 5-Aza-2'-deoxycytidine (5-Aza-CdR) has significant therapeutic value for the treatment of patients with myelodysplastic syndrome (MDS), acute myeloid leukemia (AML) and chronic myeloid leukemia (CML). The demethylating effect of 5-Aza-CdR has been well characterized. In contrast, less is known about the molecular events downstream of the methylation inhibition. Here, 5-Aza-CdR...

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PMID: 15609309
DOI: 10.1002/ijc.20797

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