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Article

p53 stabilization induces apoptosis in chronic myeloid leukemia blast crisis cells.

Leukemia - 1 May 2011

Peterson L F, Mitrikeska E, Giannola D, Lui Y, Sun H, Bixby D, Malek S N, Donato N J, Wang S, Talpaz M

Abstract excerpt

Philadelphia chromosome positive chronic myeloid leukemia has a progressive course starting in a benign phase and terminating in a blastic phase. In this study, we show that human homolog double minute 2 (HDM2) inhibition, with MI-219-a novel compound, and consequently p53 stabilization induce chronic myeloid leukemia (CML) blast crisis cells to undergo apoptosis regardless of the presence of the T315I mutation...

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Source

Identifiers

PMID: 21350558
DOI: 10.1038/leu.2011.7

Genes

BCR
FAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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