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Article

p53-induced apoptosis in the human T-ALL cell line CCRF-CEM.

Oncogene - 13 Nov 1997

Geley S, Hartmann B L, Hattmannstorfer R, Löffler M, Ausserlechner M J, Bernhard D, Sgonc R, Strasser-Wozak E M, Ebner M, Auer B, Kofler R

Abstract excerpt

The tumor suppressor p53 has been implicated in apoptosis induction and is mutated in human T-ALL CCRF-CEM cells. To investigate possible consequences of wild-type p53 loss, we reconstituted CEM-C7H2, a subclone of CCRF-CEM, with a temperature-sensitive p53 allele (p53ts). Stably transfected lines expressed high levels of p53ts and shift to the permissive temperature (32 degrees C) caused rapid induction of...

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PMID: 9395239
DOI: 10.1038/sj.onc.1201399

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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