Article
Rac-WAVE2 signaling is involved in the invasive and metastatic phenotypes of murine melanoma cells.
Oncogene - 17 Feb 2005
Kurisu Shusaku, Suetsugu Shiro, Yamazaki Daisuke, Yamaguchi Hideki, Takenawa Tadaomi
Abstract excerpt
WAVEs (WASP-family verprolin-homologous proteins) regulate the actin cytoskeleton through activation of Arp2/3 complex. As cell motility is regulated by actin cytoskeleton rearrangement and is required for tumor invasion and metastasis, blocking actin polymerization may be an effective strategy to prevent tumor dissemination. We show that WAVEs, especially WAVE2, are essential for invasion and metastasis of...
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