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Article

Wave2 activates serum response element via its VCA region and functions downstream of Rac.

Experimental cell research - 10 Dec 2004

Ishiguro Kazuhiro, Cao Zhifang, Ilasca Marco Lopez, Ando Takafumi, Xavier Ramnik

Abstract excerpt

WAVE2 is a member of the WASP/WAVE family of protein effectors of actin reorganization and cell movement. In this report, we demonstrate that WAVE2 overexpression induces serum response element (SRE) activation through serum response factor. A WAVE2 mutant lacking the VCA region did not induce SRE activation and actin polymerization. WAVE2-induced SRE activation was blocked by exposure of cells to Latrunculin A,...

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Identifiers

PMID: 15530867
DOI: 10.1016/j.yexcr.2004.09.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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