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Article

Crystal structure of the polysialic acid-degrading endosialidase of bacteriophage K1F.

Nature structural & molecular biology - 1 Jan 2005

Stummeyer Katharina, Dickmanns Achim, Mühlenhoff Martina, Gerardy-Schahn Rita, Ficner Ralf

Abstract excerpt

Phages infecting the polysialic acid (polySia)-encapsulated human pathogen Escherichia coli K1 are equipped with capsule-degrading tailspikes known as endosialidases, which are the only identified enzymes that specifically degrade polySia. As polySia also promotes cellular plasticity and tumor metastasis in vertebrates, endosialidases are widely applied in polySia-related neurosciences and cancer research. Here...

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PMID: 15608653
DOI: 10.1038/nsmb874

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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