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Article

Arg314 is essential for catalysis by N-acetyl neuraminic acid synthase from Neisseria meningitidis.

Biochemistry - 16 Apr 2013

Joseph Dmitri D A, Jiao Wanting, Parker Emily J

Abstract excerpt

The sialic acid N-acetylneuraminic acid (NANA) has a key role in the pathogenesis of a select number of neuroinvasive bacteria such as Neisseria meningitidis. These pathogens coat themselves with polysialic acids, mimicking the exterior surface of mammalian cells and consequentially concealing the bacteria from the host's immune system. NANA is synthesized in bacteria by the homodimeric enzyme NANA synthase...

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PMID: 23534460
DOI: 10.1021/bi400062c

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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