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Article

A new sialidase mechanism: bacteriophage K1F endo-sialidase is an inverting glycosidase.

The Journal of biological chemistry - 26 Jun 2009

Morley Thomas J, Willis Lisa M, Whitfield Chris, Wakarchuk Warren W, Withers Stephen G

Abstract excerpt

Bacteriophages specific for Escherichia coli K1 express a tailspike protein that degrades the polysialic acid coat of E. coli K1 that is essential for bacteriophage infection. This enzyme is specific for polysialic acid and is a member of a family of endo-sialidases. This family is unusual because all other previously reported sialidases outside of this family are exo- or trans-sialidases. The recently determined...

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Identifiers

PMID: 19411257
DOI: 10.1074/jbc.M109.003970
PMCID: PMC2719380

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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