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Article

The K5 lyase KflA combines a viral tail spike structure with a bacterial polysaccharide lyase mechanism.

The Journal of biological chemistry - 30 Jul 2010

Thompson James E, Pourhossein Meraj, Waterhouse Amy, Hudson Thomas, Goldrick Marie, Derrick Jeremy P, Roberts Ian S

Abstract excerpt

K5 lyase A (KflA) is a tail spike protein (TSP) encoded by a K5A coliphage, which cleaves K5 capsular polysaccharide, a glycosaminoglycan with the repeat unit [-4)-betaGlcA-(1,4)- alphaGlcNAc(1-], displayed on the surface of Escherichia coli K5 strains. The crystal structure of KflA reveals a trimeric arrangement, with each monomer containing a right-handed, single-stranded parallel beta-helix domain. Stable...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20519506
DOI: 10.1074/jbc.M110.127571
PMCID: PMC2911314

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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