Article

Structural Basis for Dual Peptidoglycan Hydrolysis by an <i>E. faecium Minhovirus</i> Tail Spike Lysin

2026-03-12

Abstract excerpt

Bacteriophages rely on breaching the bacterial cell wall as the first step of infection. We characterise ORF11, a putative tail-spike lysin from the 19 kbp Minhovirus SHEF14, a podovirus infecting Enterococcus faecium . Bioinformatic analyses indicate that ORF11 comprises four domains: a predicted glycosyl hydrolase (D1) a cysteine, histidine-dependent amidohydrolases/peptidases (CHAP, D4), separated by a helica...

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Literature Corpus work: d26b7560-d6a4-5a54-beea-9b6a3af440f8
DOI: 10.64898/2026.03.11.711020

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