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Article

Genetic determinants of warfarin maintenance dose and time in therapeutic treatment range: a RE-LY genomics substudy.

Pharmacogenomics - 1 Aug 2016

Eriksson Niclas, Wallentin Lars, Berglund Lars, Axelsson Tomas, Connolly Stuart, Eikelboom John, Ezekowitz Michael, Oldgren Jonas, Paré Guillaume, Reilly Paul, Siegbahn Agneta, Syvanen Ann-Christine, Wadelius Claes, Yusuf Salim, Wadelius Mia

Abstract excerpt

AIMS: We investigated associations between genetic variation in candidate genes and on a genome-wide scale with warfarin maintenance dose, time in therapeutic range (TTR), and risk of major bleeding. MATERIALS & METHODS: In total, 982 warfarin-treated patients from the RE-LY trial were studied. RESULTS: After adjusting for SNPs in VKORC1 and CYP2C9, SNPs in DDHD1 (rs17126068) and NEDD4 (rs2288344) were associated...

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Source

Identifiers

PMID: 27488176
DOI: 10.2217/pgs-2016-0061

Genes

TTR
VKORC1
ASPH
DDHD1
NEDD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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