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Article

Common genetic variants of microsomal epoxide hydrolase affect warfarin dose requirements beyond the effect of cytochrome P450 2C9.

Clinical pharmacology and therapeutics - 1 May 2005

Loebstein Ronen, Vecsler Manuela, Kurnik Daniel, Austerweil Naomi, Gak Eva, Halkin Hillel, Almog Shlomo

Abstract excerpt

BACKGROUND: Warfarin dose response is partially explained by the polymorphisms in the cytochrome P450 (CYP) 2C9 gene, affecting S -warfarin clearance, as well as by age and body weight. We examined the influence on warfarin dose requirements of candidate genes encoding microsomal epoxide hydrolase (mEH), as well as glutathione S -transferase A1 (GSTA1) components of vitamin K epoxide reductase and the...

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Source

Identifiers

PMID: 15900282
DOI: 10.1016/j.clpt.2005.01.010

Genes

GGCX
GSTA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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