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Article

Lack of sustained regression of c-MYC-induced mammary adenocarcinomas following brief or prolonged MYC inactivation.

Cancer cell - 1 Dec 2004

Boxer Robert B, Jang Joanne W, Sintasath Louis, Chodosh Lewis A

Abstract excerpt

Recent studies of oncogene dependence in conditional transgenic mice have suggested the exciting possibility that transient or prolonged MYC inactivation may be sufficient for sustained reversal of the tumorigenic process. In contrast, we report here that following oncogene downregulation, the majority of c-MYC-induced mammary adenocarcinomas grow in the absence of MYC overexpression. In addition, residual...

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Source

Identifiers

PMID: 15607962
DOI: 10.1016/j.ccr.2004.10.013

Genes

MYC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Lack of sustained regression of c-MYC-induced mammary adenocarcinomas following brief or prolonged MYC inactivation.PMID 15607962Read ↗

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Developmental context determines latency of MYC-induced tumorigenesis.Semantic proximity Read ↗

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Lack of cyclin-dependent kinase 4 inhibits c-myc tumorigenic activities in epithelial tissues.Semantic proximity Read ↗

Sustained regression of tumors upon MYC inactivation requires p53 or thrombospondin-1 to reverse the angiogenic switchSemantic proximity Read ↗

Analysis of C-MYC function in normal cells via conditional gene-targeted mutation.Semantic proximity Read ↗

Transactivation-defective c-MycS retains the ability to regulate proliferation and apoptosis.Semantic proximity Read ↗

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