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Article

Lymphomas that recur after MYC suppression continue to exhibit oncogene addiction.

Proceedings of the National Academy of Sciences of the United States of America - 18 Oct 2011

Choi Peter S, van Riggelen Jan, Gentles Andrew J, Bachireddy Pavan, Rakhra Kavya, Adam Stacey J, Plevritis Sylvia K, Felsher Dean W

Abstract excerpt

The suppression of oncogenic levels of MYC is sufficient to induce sustained tumor regression associated with proliferative arrest, differentiation, cellular senescence, and/or apoptosis, a phenomenon known as oncogene addiction. However, after prolonged inactivation of MYC in a conditional transgenic mouse model of Eμ-tTA/tetO-MYC T-cell acute lymphoblastic leukemia, some of the tumors recur, recapitulating what...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Neoplasm Recurrence, Local

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Source

Open in PubMed Open full text

Identifiers

PMID: 21969595
DOI: 10.1073/pnas.1107303108
PMCID: PMC3198348

Genes

MYC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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