Article
Sustained loss of a neoplastic phenotype by brief inactivation of MYC.
Science (New York, N.Y.) - 5 Jul 2002
Jain Meenakshi, Arvanitis Constadina, Chu Kenneth, Dewey William, Leonhardt Edith, Trinh Maxine, Sundberg Christopher D, Bishop J Michael, Felsher Dean W
Abstract excerpt
Pharmacological inactivation of oncogenes is being investigated as a possible therapeutic strategy for cancer. One potential drawback is that cessation of such therapy may allow reactivation of the oncogene and tumor regrowth. We used a conditional transgenic mouse model for MYC-induced tumorigenesis to demonstrate that brief inactivation of MYC results in the sustained regression of tumors and the...
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