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A fibroin secretion-deficient silkworm mutant, Nd-sD, provides an efficient system for producing recombinant proteins.

Insect biochemistry and molecular biology - 1 Jan 2005

Inoue Satoshi, Kanda Toshio, Imamura Morikazu, Quan Guo-Xing, Kojima Katsura, Tanaka Hiromitsu, Tomita Masahiro, Hino Rika, Yoshizato Katsutoshi, Mizuno Shigeki, Tamura Toshiki

Abstract excerpt

The silkworm Nd-s(D) mutant is silk fibroin-secretion deficient. In the mutant, a disulfide linkage between the heavy (H) and light (L) chains, which is essential for the intracellular transport and secretion of fibroin, is not formed because of a partial deletion of the L-chain gene. To utilize the inactivity of the mutant L-chain, we investigated the possibility of using the Nd-s(D) mutant for the efficient...

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PMID: 15607655
DOI: 10.1016/j.ibmb.2004.10.002

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