Article
Mechanism of the growth and development of the posterior silk gland and silk secretion revealed by mutation of the fibroin light chain in silkworm.
International journal of biological macromolecules - 1 Oct 2021
Ye Xiaogang, Tang Xiaoli, Zhao Shuo, Ruan Jinghua, Wu Meiyu, Wang Xiaoxiao, Li Huiping, Zhong Boxiong
Abstract excerpt
Silkworm, as a model organism, has very high economic value due to its silk secretion ability. Although a large number of studies have attempted to elucidate the mechanism of silk secretion, it remains unclear. In this study, the fibroin light chain (Fib-L) gene of silkworm was subjected to CRISPR/Cas9 editing, which yielded premature termination of translation at 135 aa. Compared with those of the wild type, the...
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