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Article

Antibody framework residues affecting the conformation of the hypervariable loops.

Journal of molecular biology - 20 Mar 1992

Foote J, Winter G

Abstract excerpt

Rodent monoclonal antibodies have been "humanized" or "reshaped" for therapy by transplanting the antigen-binding loops from their variable domains onto the beta-sheet framework regions of human antibodies. However, additional substitutions in the human framework regions are sometimes required for high affinity antigen binding. Here we describe antigen binding by a reshaped antibody derived from the mouse...

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PMID: 1560463
DOI: 10.1016/0022-2836(92)91010-m

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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