Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

PKCepsilon overexpression, irrespective of genetic background, sensitizes skin to UVR-induced development of squamous-cell carcinomas.

The Journal of investigative dermatology - 1 Jan 2010

Sand Jordan M, Aziz Moammir H, Dreckschmidt Nancy E, Havighurst Thomas C, Kim KyungMann, Oberley Terry D, Verma Ajit K

Abstract excerpt

Chronic exposure to UVR is the major etiologic factor in the development of human skin cancers including squamous-cell carcinoma (SCC). We have previously shown that protein Kinase C epsilon (PKCepsilon) transgenic mice on FVB/N background, which overexpress PKCepsilon protein approximately eightfold over endogenous levels in epidermis, exhibit about threefold more sensitivity than wild-type littermates to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dose-Response Relationship, Radiation
Share to Epidermis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Extracellular Signal-Regulated MAP Kinases

Share to Mice, Hairless

Share to Proliferating Cell Nuclear Antigen

Share to Protein Kinase C-epsilon

Share to STAT3 Transcription Factor

Share to Ultraviolet Rays

Source

Open in PubMed Open full text

Identifiers

PMID: 19626035
DOI: 10.1038/jid.2009.212
PMCID: PMC2794925

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

PKCepsilon overexpression, irrespective of genetic background, sensitizes skin to UVR-induced development of squamous-cell carcinomas.PMID 19626035Read ↗

Transgenic mice overexpressing protein kinase C epsilon in their epidermis exhibit reduced papilloma burden but enhanced carcinoma formation after tumor promotion.Semantic proximity Read ↗

Crucial role of phospholipase Cepsilon in chemical carcinogen-induced skin tumor development.Semantic proximity Read ↗

Ultraviolet irradiation induces keratinocyte proliferation and epidermal hyperplasia through the activation of the epidermal growth factor receptor.Semantic proximity Read ↗

Early epidermal destruction with subsequent epidermal hyperplasia is a unique feature of the papilloma-independent squamous cell carcinoma phenotype in PKCepsilon overexpressing transgenic mice.Semantic proximity Read ↗

Impact of global genome repair versus transcription-coupled repair on ultraviolet carcinogenesis in hairless mice.Semantic proximity Read ↗

Differential tumor biology effects of double-initiation in a mouse skin chemical carcinogenesis model comparing wild type versus protein kinase Cepsilon overexpression mice.Semantic proximity Read ↗

Patches of mutant p53-immunoreactive epidermal cells induced by chronic UVB Irradiation harbor the same p53 mutations as squamous cell carcinomas in the skin of hairless SKH-1 mice.Semantic proximity Read ↗

Enhanced Spontaneous Skin Tumorigenesis and Aberrant Inflammatory Response to UVB Exposure in Immunosuppressed Human Papillomavirus Type 8‒Transgenic MiceSemantic proximity Read ↗

Reduction in IkappaB kinase alpha expression promotes the development of skin papillomas and carcinomas.Semantic proximity Read ↗

Spontaneous squamous cell carcinoma induced by the somatic inactivation of retinoblastoma and Trp53 tumor suppressors.Semantic proximity Read ↗

Deletion of prostaglandin E2 EP2 receptor protects against ultraviolet-induced carcinogenesis, but increases tumor aggressiveness.Semantic proximity Read ↗

c-Jun regulates eyelid closure and skin tumor development through EGFR signaling.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.