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Article

Reduction in IkappaB kinase alpha expression promotes the development of skin papillomas and carcinomas.

Cancer research - 1 Oct 2007

Park Eunmi, Zhu Feng, Liu Bigang, Xia Xiaojun, Shen Jianjun, Bustos Tracie, Fischer Susan M, Hu Yinling

Abstract excerpt

We reported recently a marked reduction in IkappaB kinase alpha (IKKalpha) expression in a large proportion of human poorly differentiated squamous cell carcinomas (SCC) and the occurrence of Ikkalpha mutations in human SCCs. In addition, overexpression of IKKalpha in the epidermis inhibited the development of skin carcinomas and metastases in mice. However, whether a reduction in IKKalpha expression promotes...

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Source

Identifiers

PMID: 17909021
DOI: 10.1158/0008-5472.CAN-07-0590

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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