Article
Dopamine transporter gene associated with diminished subjective response to amphetamine.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Mar 2005
Lott David C, Kim Soo-Jeong, Cook Edwin H, de Wit Harriet
Abstract excerpt
Individual variability in responses to stimulant drugs may influence risk of stimulant abuse and treatment response. However, the genetic determinants of this variability have yet to be elucidated. The dopamine transporter is an important site of amphetamine action. Therefore, the dopamine transporter gene (DAT1) is a logical candidate gene to study. Using a drug challenge approach, we tested for association...
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